Dipartimento di Ingegneria Elettrica

Contenuti del sito

Contenuto della pagina - Torna all'inizio

Torti pubblicazioni

Elenco delle pubblicazioni (dal 2005)

Moro L, Reineri S, Piranda D, Pietrapiana D, Lova P, Bertoni A, Graziani A, Defilippi P, Canobbio I, Torti M, Sinigaglia F.
Nongenomic effects of 17β-estradiol in human platelets: potentiation of thrombin-induced aggregation through estrogen receptor β and Src kinase.
Blood. 2005; 105:115-21.

Guidetti GF, Bartolini B, Bernardi B, Tira ME, Berndt MC, Balduini C, Torti M.
Binding of von Willebrand factor to the small proteoglycan decorin.
FEBS Lett. 2004; 574:95-100.

Canobbio I, Balduini C, Torti M.
Signalling through the platelet glycoprotein Ib-V-IX complex.
Cell Signal. 2004; 16:1329-44.

Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M.
Expression, activation, and subcellular localization of the Rap1 GTPase in cordblood-derived human megakaryocytes.
Exp Cell Res. 2004; 300:84-93.

Pietrocola G, Schubert A, Visai L, Torti M, Fitzgerald JR, Foster TJ,Reinscheid DJ, Speziale P.
FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation.
Blood. 2005; 105:1052-9.

Greco F, Sinigaglia F, Balduini C, Torti M.
Activation of the small GTPase Rap2B in agonist-stimulated human platelets.
J Thromb Haemost. 2004; 2:2223-30.

Campus F, Lova P, Bertoni A, Sinigaglia F, Balduini C, Torti M.
Thrombopoietin complements Gi- but not Gq-dependent pathways for integrin αIIbβ3 activation and platelet aggregation.
J Biol Chem. 2005; 280:24386-95.

Canobbio I, Noris P, Pecci A, Balduini A, Balduini CL, Torti M.
Altered cytoskeleton organization in platelets from patients with MYH9-related disease.
J Thromb Haemost. 2005;3:1026-35.

Pecci A, Canobbio I, Balduini A, Stefanini L, Cisterna B, Marseglia C, Noris P, Savoia A, Balduini CL, Torti M.
Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.
Hum Mol Genet. 2005; 14:3169-78.

Canobbio I, Stefanini L, Guidetti GF, Balduini C, Torti M.
A new role for FcγRIIA in the potentiation of human platelet activation induced by weak stimulation.
Cell Signal. 2006; 18:861-70.

Paganini S, Guidetti GF, Catricalā S, Trionfini P, Panelli S, Balduini C, Torti M.
Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.
Biochimie. 2006; 88:285-95.

Balzac F, Avolio M, Degani S, Kaverina I, Torti M, Silengo L, Small JV, Retta SF.
E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function.
J Cell Sci. 2005; 118:4765-83.

Falcinelli E, Guglielmini G, Torti M, Gresele P.
Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation.
J Thromb Haemost. 2005; 3:2526-35.

Bernardi B, Guidetti GF, Campus F, Crittenden JR, Graybiel AM, Balduini C, Torti M.
The small GTPase Rap1b regulates the cross talk between platelet integrin α2β1 and integrin αIIbβ3.
Blood. 2006; 107:2728-35.

Noris P, Guidetti GF, Conti V, Ceresa IF, Di Pumpo M, Pecci A, Torti M, Savoia A, Balduini CL.
Autosomal dominant thrombocytopenias with reducedexpression of glycoprotein Ia.
Thromb Haemost. 2006; 95:483-9.

Greco F, Ciana A, Pietra D, Balduini C, Minetti G, Torti M.
Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation.
Biochim Biophys Acta. 2006; 1763:330-5.

Reineri S, Bertoni A, Sanna E, Baldassarri S, Sarasso C, Zanfa M, Canobbio I, Torti M, Sinigaglia F.
Membrane lipid rafts coordinate estrogen-dependent signaling in human platelets.
Biochim Biophys Acta. 2007; 1773:273-8.

Ghilotti M, Lova P, Balduini C, Torti M.
Epinephrine induces intracellular Ca2+ mobilization in thrombin-desensitized platelets: a role for GPIb-IX-V.
Platelets. 2007; 18:135-42.

Mancini F, Rigacci S, Berti A, Balduini C, Torti M.
The low-molecular-weight phosphotyrosine phosphatase is a negative regulator of FcγRIIA-mediated cell activation.
Blood. 2007; 110:1871-8.

Canobbio I, Trionfini P, Guidetti GF, Balduini C, Torti M.
Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets.
Cell Signal. 2008; 20:1662-70.

Baldassarri S, Bertoni A, Bagarotti A, Sarasso C, Zanfa M, Catani MV, Avigliano L, Maccarrone M, Torti M, Sinigaglia F.
The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors.
J Thromb Haemost. 2008; 6:1772-9.

Balduini A, Pallotta I, Malara A, Lova P, Pecci A, Viarengo G, Balduini CL, Torti M.
Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes.
J Thromb Haemost. 2008; 6:1900-7.

Guidetti GF, Lova P, Bernardi B, Campus F, Baldanzi G, Graziani A, Balduini C,Torti M.
The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets.
J Biol Chem. 2008; 283:28795-805.

Balduini A, Malara A, Pecci A, Badalucco S, Bozzi V, Pallotta I, Noris P, Torti M, Balduini CL.
Proplatelet formation in heterozygous bernard-soulier syndrome type Bolzano.
J Thromb Haemost. 2008 6:1900-7

Guidetti GF, Bernardi B, Consonni A, Rizzo P, Gruppi C, Balduini C, Torti M.
Integrin α2β1 induces phosphorylation-dependent and phosphorylation-independent activation of phospholipase Cγ2 in platelets: role of Src kinase and Rac GTPase.
J Thromb Haemost. 2009; 7:1200-6.

Canobbio I, Stefanini L, Cipolla L, Ciraolo E, Gruppi C, Balduini C, Hirsch E, Torti M.
Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets.
Blood. 2009; 114: 2193-6.

Pecci A, Malara A, Badalucco S, Bozzi V, Torti M, Balduini CL, Balduini A.
Megakaryocytes of patients with MYH9-related thrombocytopenia present an altered proplatelet formation.
Thromb Haemost. 2009; 102: 90-6.

Lova P, Canobbio I, Guidetti GF, Balduini C, Torti M.
Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V.
Cell Signal. 2010; 22: 1681-7.

Catricalā S, Guidetti GF, Canobbio I, Pecci A, Balduini CL, Balduini C, Torti M.
The irreversibility of platelet aggregation is regulated by myosin IIA, but is not compromised in MYH9-related disease.
Thromb Res. 2011; 127: 171-3.

Lova P, Guidetti GF, Canobbio I, Catricalā S, Balduini C, Torti M.
Epinephrine-mediated protein kinase C and Rap1b activation requires the co-stimulation of Gz-, Gq-, and Gi-coupled receptors.
Thromb Haemost. 2011; 105: 479-86.

Canobbio I, Catricalā S, Balduini C, Torti M.
Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.
Biochim Biophys Acta. 2011; 1813: 500-6.

Consonni A, Cipolla L, Guidetti G, Canobbio I, Ciraolo E, Hirsch E, Falasca M, Okigaki M, Balduini C, Torti M.
Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.
Blood. 2012; 119: 847-56.

Guidetti GF, Consonni A, Cipolla L, Mustarelli P, Balduini C, Torti M.
Nanoparticles induce platelet activation in vitro through stimulation of canonical signalling pathways.
Nanomedicine. 2012; 8: 1329-36.

Guidetti GF, Torti M.
The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors.
J Signal Transduct. 2012; 2012: 412089.

Catricala' S, Torti M, Ricevuti G.
Alzheimer disease and platelets: how's that relevant.
Immun Ageing. 2012; 9: 20.

Canobbio I, Cipolla L, Consonni A, Momi S, Guidetti G, Oliviero B, Falasca M, Okigaki M, Balduini C, Gresele P, Torti M.
Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca(2+)-dependent tyrosine kinase Pyk2.
Blood. 2013; 121: 648-57.

Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M.
The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.
J Thromb Haemost. 2013; 11: 345-56.

Guidetti GF, Manganaro D, Consonni A, Canobbio I, Balduini C, Torti M.
Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase.
Biochem J. 2013; 453: 115-23.

Kim S, Cipolla L, Guidetti G, Okigaki M, Jin J, Torti M, Kunapuli SP.
Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.
J Biol Chem. 2013; 288: 18194-203.

Canobbio I, Catricalā S, Di Pasqua LG, Guidetti G, Consonni A, Manganaro D, Torti M.
Immobilized amyloid Aβ peptides support platelet adhesion and activation.
FEBS Lett. 2013; 587: 2606-11.

Guidetti GF, Torti M.
Pull-down assay for analysis of integrin-mediated activation of Rap proteins in adherent platelets.
Methods Mol Biol. 2014; 1120:167-76.

Achilli C, Jadhav SA, Guidetti GF, Ciana A, Abbonante V, Malara A, Fagnoni M, Torti M, Balduini A, Balduini C, Minetti G.
Folic acid-conjugated 4-amino-phenylboronate, a boron-containing compound designed for boron neutron capture therapy, is an unexpected agonist for human neutrophils and platelets.
Chem Biol Drug Des. 2014; 83: 532-40.

Canobbio I, Guidetti GF, Oliviero B, Manganaro D, Vara D, Torti M, Pula G.
Amyloid β-peptide-dependent activation of human platelets: essential role for Ca2+ and ADP in aggregation and thrombus formation.
Biochem J. 2014; 462: 513-23.

Carrim N, Walsh TG, Consonni A, Torti M, Berndt MC, Metharom P.
Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation.
PLoS One. 2014; 9: e113679.

Torti M.
PI3Kβ inhibition: all that glitters is not gold.
Blood. 2015; 125: 750-1.

Canobbio I, Abubaker AA, Visconte C, Torti M, Pula G.
Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease.
Front Cell Neurosci. 2015; 9: 65

Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW.
Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α.
Arterioscler Thromb Vasc Biol. 2015; 35: 1374-81.

Manganaro D, Consonni A, Guidetti GF, Canobbio I, Visconte C, Kim S, Okigaki M, Falasca M, Hirsch E, Kunapuli SP, Torti M.
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role ofPyk2 and c-Cbl.
Biochim Biophys Acta. 2015; 1853: 1879-88.

Canobbio I, Cipolla L, Guidetti GF, Manganaro D, Visconte C, Kim S, Okigaki M, Falasca M, Kunapuli SP, Torti M.
The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets.
Biochem J. 2015; 469: 199-210.

Guidetti GF, Canobbio I, Torti M.
PI3K/Akt in platelet integrin signaling and implications in thrombosis.
Adv Biol Regul. 2015; 59: 36-52